GLP-1 Before and After: Real Results by Month (Photos and Data)
In SURMOUNT-1, people on tirzepatide 15 mg weekly lost 20.9% of their body weight on average over 72 weeks, against 3.1% on placebo.
- Average loss, top dose
- 20.9%
- On placebo
- 3.1%
- Trial length
- 72 weeks
- Trial
- SURMOUNT-1
Weight loss and half-life overview
Half-life in days means how long your body takes to clear half a dose, based on section 12.3 of each FDA label.
Percentage of body weight. The trials, doses, and lengths varied, so compare each result with its own placebo on its page.
First, the GLP-1 numbers before and after
Each GLP-1 is shown at its highest dose tested in the main weight trial. Different trials enrolled different people.
| Trial | Dose group | Average weight lost | Placebo or comparison | Weeks | Who was in it |
|---|---|---|---|---|---|
| STEP 1 | Semaglutide 2.4 mg weekly | 14.9% | 2.4% | 68 | Adults with obesity or overweight, without diabetes |
| OASIS 4 | Wegovy pill 25 mg daily | 13.6% | 2.4% | 64 | Adults with obesity or overweight, without diabetes |
| SURMOUNT-1 | Tirzepatide 15 mg weekly | 20.9% | 3.1% | 72 | Adults with obesity or overweight, without diabetes |
| SURMOUNT-2 | Tirzepatide 15 mg weekly | 14.7% | 3.2% | 72 | Adults with obesity or overweight but no type 2 diabetes |
| SCALE Obesity and Prediabetes | Liraglutide 3.0 mg daily | 7.4% | 3% | 56 | Adults with obesity or overweight who also have type 2 diabetes |
| ATTAIN-1 | Foundayo 17.2 mg daily | 11.1% | 2.1% | 72 | Adults with obesity or overweight, without diabetes |
| ATTAIN-2 | Foundayo 17.2 mg daily | 9.6% | 2.5% | 72 | Adults with obesity or overweight but no type 2 diabetes |
| STEP 2 | Semaglutide 2.4 mg weekly | 9.6% | 3.4% | 68 | Adults with obesity or overweight but no type 2 diabetes |
Sources: STEP 1 (FDA label (DailyMed)), SURMOUNT-1 (FDA label (DailyMed)), SURMOUNT-2 (PubMed), SCALE Obesity and Prediabetes (FDA label (DailyMed)), ATTAIN-1 (FDA label (DailyMed)), STEP 2 (PubMed).
First, the GLP-1 numbers before and after
The trial average of 20.9% was applied to three starting weights. Simple math only, not a prediction for one person: some lose more, while others lose less.
| Starting weight | Average loss on tirzepatide 15 mg weekly | Average loss on placebo |
|---|---|---|
| 180 lb | about 38 lb | about 6 lb |
| 220 lb | about 46 lb | about 7 lb |
| 260 lb | about 54 lb | about 8 lb |
Sources: FDA label (DailyMed).
Week-by-week view
- During the first weeks, stomach side effects occur most often when the dose remains low and continues to rise. After every dose increase, they often return for a few days.
- Week 72: SURMOUNT-1 ended here, which is when the average loss shown above was measured.
Section sources: health.clevelandclinic.org, DailyMed FDA label.
What makes it stall, and what helps
- See where you are in the dose steps. Lower doses led to less weight loss in every trial listed above.
- Over the last month, count the doses you missed or took late.
- For a few days, record your food and drink. Calories add up from drinks and grazing as your portions get smaller.
- Talk with your prescriber about thyroid testing or blood sugar testing. If your progress has stayed flat for months, also discuss changing medicines.
Every living with it page
All GLP-1 medicines
- Amycretin Weight Loss
- CagriSema Weight Loss
- GLP-1 Diet
- GLP-1 Foods to Avoid
- GLP-1 Not Working? The Checklist, in Order
- GLP-1 Plateau
- GLP-1 Protein Intake
- GLP-1 Results
- GLP-1 Reviews
- GLP-1 Timeline
- Mazdutide Weight Loss
- New Weight Loss Drugs
- Pemvidutide Weight Loss
- Stopping GLP-1
- Survodutide Weight Loss
- What r/glp1 Reports vs the Trials
- What Weight-Loss Drug Did Elon Musk Take? Plus the Fake Cure Ads
Ozempic
- Celebrities on Ozempic
- How to Not Gain Weight After Stopping Ozempic
- Oh Oh Oh Ozempic
- Ozempic and Blood Sugar
- Ozempic and Carbs
- Ozempic and Creatine
- Ozempic and Exercise
- Ozempic and Intermittent Fasting
- Ozempic and Keto
- Ozempic and Vitamins
- Ozempic Before and After
- Ozempic Diet
- Ozempic FDA Approval
- Ozempic Foods to Avoid (and Why They Trigger Nausea and Reflux)
- Ozempic Lawsuit
- Ozempic Meal Plan
- Ozempic Not Working? The Checklist, in Order
- Ozempic on Reddit
- Ozempic Plateau
- Ozempic Results
- Ozempic Reviews
- Ozempic Timeline
- Ozempic Trial
- Protein on Ozempic
Wegovy
- Protein on Wegovy
- Stopping Wegovy
- Wegovy and Creatine
- Wegovy and Exercise
- Wegovy and Intermittent Fasting
- Wegovy and Keto
- Wegovy and Sugar
- Wegovy and Vitamins
- Wegovy Before and After
- Wegovy Diet
- Wegovy FDA Approval History
- Wegovy Foods to Avoid (and Why They Trigger Nausea and Reflux)
- Wegovy Lawsuit
- Wegovy Not Working? The Reasons and What to Do at Each Stage
- Wegovy Pill Reviews
- Wegovy Plateau
- Wegovy Reddit
- Wegovy Results by Week and Month
- Wegovy Reviews
- Wegovy Timeline
- Wegovy Weight Loss Study
Mounjaro
- How Effective Is Mounjaro? Every Trial's A1C and Weight Numbers
- Mounjaro and Creatine
- Mounjaro and Exercise
- Mounjaro and Intermittent Fasting
- Mounjaro and Keto
- Mounjaro and Vitamins
- Mounjaro Before and After
- Mounjaro Diet
- Mounjaro FDA Approval
- Mounjaro Foods to Avoid (and Why They Trigger Nausea and Reflux)
- Mounjaro Lawsuit Explained
- Mounjaro Not Working? The Checklist, in Order
- Mounjaro Reddit
- Mounjaro Reviews
- Mounjaro Timeline
- Protein on Mounjaro
- Stopping Mounjaro
Semaglutide
- Protein on Semaglutide
- Semaglutide and Creatine
- Semaglutide and Exercise
- Semaglutide and Intermittent Fasting
- Semaglutide and Keto
- Semaglutide and Vitamins
- Semaglutide Before and After
- Semaglutide Diet
- Semaglutide FDA Approvals and Warnings
- Semaglutide Foods to Avoid and Why They Trigger Nausea
- Semaglutide Lawsuit
- Semaglutide Not Working? The Checklist, in Order
- Semaglutide on Reddit
- Semaglutide Results
- Semaglutide Reviews
- Semaglutide Trials in Plain English
- Stopping Semaglutide
Zepbound
- Stopping Zepbound
- Zepbound and Creatine
- Zepbound and Exercise
- Zepbound and Intermittent Fasting
- Zepbound and Keto
- Zepbound and Vitamins
- Zepbound Diet
- Zepbound Foods to Avoid (and Why They Trigger Nausea and Reflux)
- Zepbound Lawsuit
- Zepbound Meal Plan
- Zepbound Not Working? The Checklist, in Order
- Zepbound Plateau
- Zepbound Protein Calculator
- Zepbound Reddit
- Zepbound Results
- Zepbound Reviews
- Zepbound Timeline
Tirzepatide
- Protein on Tirzepatide
- Stopping Tirzepatide
- Tirzepatide and Creatine
- Tirzepatide and Exercise
- Tirzepatide and Intermittent Fasting
- Tirzepatide and Keto
- Tirzepatide and Vitamins
- Tirzepatide Before and After
- Tirzepatide Diet
- Tirzepatide FDA Approvals
- Tirzepatide Lawsuit
- Tirzepatide Not Working? Causes by Dose and Week, and Fixes
- Tirzepatide on Reddit
- Tirzepatide Results by Week
- Tirzepatide Timeline
- Tirzepatide Trial
Liraglutide
- Liraglutide (Saxenda) Before and After
- Liraglutide Diet
- Liraglutide FDA Approval
- Liraglutide Foods to Avoid and Why They Trigger Nausea
- Liraglutide Lawsuit
- Liraglutide Meal Plan
- Liraglutide Not Working? The Checklist, in Order
- Liraglutide on Reddit
- Liraglutide Plateau
- Liraglutide Results
- Liraglutide Reviews
- Liraglutide Timeline
- Protein on Liraglutide
- Stopping Liraglutide
Rybelsus
- Protein on Rybelsus
- Rybelsus and Sugar
- Rybelsus Before and After
- Rybelsus Clinical Trials
- Rybelsus Diet
- Rybelsus Foods to Avoid (and Why They Trigger Nausea and Reflux)
- Rybelsus Meal Plan
- Rybelsus Not Working? The Checklist, in Order
- Rybelsus Plateau
- Rybelsus Reddit
- Rybelsus Results
- Rybelsus Reviews
- Rybelsus Timeline
- Stopping Rybelsus
Trulicity
- Protein on Trulicity
- Stopping Trulicity
- Trulicity and Sugar
- Trulicity Commercial
- Trulicity Diet
- Trulicity FDA Approval
- Trulicity Foods to Avoid (and Why They Trigger Nausea and Reflux)
- Trulicity Lawsuit Explained
- Trulicity Meal Plan
- Trulicity Not Working? The Checklist, in Order
- Trulicity Plateau
- Trulicity Results
- Trulicity Reviews
- Trulicity Timeline