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GLP-1 Decoder

Zepbound and Creatine: Is It Safe? Label, Studies

Zepbound and creatine: what the label says, what doctors advise, and practical tips.

Active ingredient
tirzepatide
Manufacturer
Eli Lilly
How it is taken
Weekly injection (pen or vial)
FDA-approved for
Weight loss, Sleep apnea
Zepbound and creatine: a morning walk on a quiet path

Zepbound in brief

How long it stays in your body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

Half-life: 5 to 6 days. Once 5.5 d pass, half is gone, and five half-lives (27.5 d) leave about 3% behind.

Weight loss in its main trial
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1 over 72 weeks, people lost 20.9% of body weight, compared with 3.1% on placebo.

Cost over time
202420252026$1,086.37$0List priceSelf-pay

Price points each month in US dollars come from the maker's price page, which lists the list price and self-pay offers.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.