Dulaglutide: Uses, How It Works, Side Effects, Cost

Dulaglutide is the active ingredient in Trulicity, from Eli Lilly. The first Dulaglutide brand, Trulicity, was FDA approved in 2014.

A look at Trulicity

The time your body holds it

With a half-life of about 5 days, after 5 d, half has left. After five half-lives (25 d), about 3% remains.

The same ingredient appears in different brands, and each brand has its own label, uses, and price.

Every Dulaglutide brand sold in the US
Brand	How it is taken	Approved for	First approved	List price
Trulicity	weekly injection	Type 2 diabetes and heart risk	2014	$1,006.93 per fill

Results for dulaglutide in the main trials
Trial	Who took part	Length	Group	A1C change
AWARD-11	Adults with type 2 diabetes on metformin	36 weeks	Dulaglutide 1.5 mg weekly	-1.54 percentage points (mean HbA1c change)
AWARD-11	Adults with type 2 diabetes on metformin	36 weeks	Dulaglutide 4.5 mg weekly	-1.77 percentage points (mean HbA1c change)

Sources: PubMed 1 2.

Each label tested different people and doses, so first compare within a single column.

These warnings come from the DailyMed FDA label.

It is not on the current FDA shortage list; Lilly says all Trulicity doses are available.

Sources: ashp.org.