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GLP-1 Decoder

Zepbound Reddit: Top r/Zepbound Questions

Zepbound reddit: the recurring themes in community discussion, set against the label.

Active ingredient
tirzepatide
Manufacturer
Eli Lilly
How it is taken
Weekly injection (pen or vial)
FDA-approved for
Weight loss, Sleep apnea

Zepbound overview

Time it stays in the body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

The half-life is 5 to 6 days. At 5.5 d, half has cleared. Following five half-lives (27.5 d), about 3% remains.

Main trial weight loss
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

Over 72 weeks in SURMOUNT-1, results were 20.9% of body weight, compared with 3.1% on placebo.

Prices over time
202420252026$1,086.37$0List priceSelf-pay

Monthly prices in US dollars show both list prices and self-pay offers. The maker's price page provides each figure.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.

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