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GLP-1 Decoder

Zepbound Reviews: Real Experiences, Sorted by Outcome

Zepbound reviews: what people report, grouped by theme, next to what the trials found.

Active ingredient
tirzepatide
Manufacturer
Eli Lilly
How it is taken
Weekly injection (pen or vial)
FDA-approved for
Weight loss, Sleep apnea
Zepbound reviews: a notebook and a weekly GLP-1 pen on a kitchen table

A quick look at Zepbound

How long it remains inside the body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

It has a half-life of 5 to 6 days. After 5.5 d, half is gone, and about 3% remains after five half-lives (27.5 days).

Weight loss in the main trial
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1 over 72 weeks, the figure was 20.9% of body weight, compared with 3.1% on placebo.

Prices over time
202420252026$1,086.37$0List priceSelf-pay

In US dollars, monthly price points include the list price and self-pay offers. Each one was read from the maker's price page.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.