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GLP-1 Decoder

Trulicity Not Working? The Checklist, in Order

A quick look at Trulicity

How long it stays in your body
100%50%25%0%05 d10 d15 d20 d25 d50%25%12.5%time after the dose

Its half-life is about 5 days: after 5 d, half is gone, and after five half-lives (25 d) about 3% is left.

Sources: FDA label (DailyMed).

What makes it stall, and what helps

  1. Check where you are in the dose steps. Every trial listed above showed less weight loss at the lower doses.
  2. Add up any missed or late doses from the past month.
  3. For a few days, write down what you eat and drink. As your portions get smaller, liquid calories and grazing add up.
  4. Have protein with every meal and keep doing your strength exercise, so fat accounts for most of the weight you lose.
  5. Your sleep and stress both change your appetite, so check both.
  6. Ask your pharmacist whether any of your other medicines can cause weight gain.
  7. Ask your prescriber about a thyroid test or a blood sugar test. If the stall has lasted for months, also talk about changing medicines.