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GLP-1 Decoder

Zepbound and Intermittent Fasting: Is It Safe? Label

Zepbound and intermittent fasting: what the label says, what doctors advise, and practical tips.

Active ingredient
tirzepatide
Manufacturer
Eli Lilly
How it is taken
Weekly injection (pen or vial)
FDA-approved for
Weight loss, Sleep apnea
Zepbound and intermittent fasting: a morning walk on a quiet path

Zepbound in short

How long it stays in your body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

The half-life is 5 to 6 days, so half is gone at 5.5 d, while five half-lives (27.5 d) leaves about 3%.

Weight loss in its main trial
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1, people lost 20.9% of body weight over 72 weeks, while the placebo group lost 3.1%.

Prices over time
202420252026$1,086.37$0List priceSelf-pay

In US dollars, monthly price points include the list price and self-pay offers. Each figure comes from the maker's price page.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.