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Tirzepatide and Intermittent Fasting: Is It Safe? Label

Tirzepatide and fasting: what the label says, what doctors advise, and practical tips.

Active ingredient
tirzepatide
Manufacturer
Eli Lilly
Tirzepatide and fasting: a morning walk on a quiet path

Zepbound in brief

How long it stays in your body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

Half-life 5 to 6 days: after 5.5 d, half is gone, while five half-lives (27.5 d) leave about 3% behind.

Body weight lost in the main trial
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

Over 72 weeks, SURMOUNT-1 reported 20.9% of body weight, compared with 3.1% on placebo.

Cost over time
202420252026$1,086.37$0List priceSelf-pay

Prices each month in US dollars: the list price and the self-pay offers, all taken from the maker's price page.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.

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