Trulicity Fatigue: How Common, How Long It Lasts, What Helps
Yes. In the Trulicity trials, 5.6% of people on 1.5 mg had fatigue, against 2.6% on placebo: about 2 times the placebo rate. It is the seventh most common side effect in that table.
- In the Trulicity label
- Yes, with a rate
- On Trulicity 1.5 mg
- 5.6%
- On placebo
- 2.6%
- Rank in the label table
- 7 of 7
A quick overview of Trulicity
The half-life is about 5 days. Half remains after 5 d, and about 3% remains after five half-lives (25 d).
Sources: FDA label (DailyMed).
Trulicity vs placebo: how often it appears
Trulicity fatigue rates for each dose group appear in the label trials. The trial’s comparison group was given a placebo.
| Medicine and dose | Fatigue | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Trulicity 0.75 mg | 4.2% | 2.6% | +1.6 points | Adults with type 2 diabetes |
| Trulicity 1.5 mg | 5.6% | 2.6% | +3 points | Adults with type 2 diabetes |
Source: Trulicity label (DailyMed).
Fatigue with Trulicity compared with other GLP-1s
Different groups of people took part in the trials reported in each label. Use this information as a rough guide.
The pill forms also appear in the table: Foundayo.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
| Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
Source: FDA label (DailyMed).