Trulicity Hypoglycemia: How Common, How Long It Lasts
The Trulicity label names hypoglycemia as a reported side effect but gives no trial rate for it.
- In the label
- Listed, no rate given
- Label term
- hypoglycemia
Trulicity overview
The half-life is about 5 days: after 5 d, half is gone, and about 3% remains after five half-lives (25 d).
Sources: FDA label (DailyMed).
What the Trulicity label provides instead
The Trulicity label gives no rate for low blood sugar. Rates are provided for the five most common side effects listed in the label.
| Side effect | Placebo | Trulicity 0.75 mg | Trulicity 1.5 mg | More than placebo, 1.5 mg |
|---|---|---|---|---|
| Nausea | 5.3% | 12.4% | 21.1% | +15.8 points |
| Vomiting | 2.3% | 6% | 12.7% | +10.4 points |
| Diarrhea | 6.7% | 8.9% | 12.6% | +5.9 points |
| Abdominal Pain | 4.9% | 6.5% | 9.4% | +4.5 points |
| Decreased Appetite | 1.6% | 4.9% | 8.6% | +7 points |
Source: Trulicity label (DailyMed).
Hypoglycemia: a comparison of Trulicity and other GLP-1s
Different groups of people were involved in the trials covered by each label. Treat it as a rough guide.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Saxenda | 12.6% | all doses | 6.6% | Adults with obesity or overweight (weight management) |
 Wegovy | 6% | 2.4 mg | 2% | Adults with obesity or overweight (weight management) |
 Ozempic | Listed, no rate given | – | – | – |
 Rybelsus | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Zepbound | Listed, no rate given | – | – | – |
 Foundayo | Listed, no rate given | – | – | – |
| Trulicity | Listed, no rate given | – | – | – |
 Victoza | Listed, no rate given | – | – | – |
| Byetta | Listed, no rate given | – | – | – |
Sources: Wegovy label (DailyMed), Saxenda label (DailyMed).
Source: the FDA label on DailyMed.
Details in the Trulicity label
These are the label's exact words on low blood sugar:
“an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia [see Adverse Reactions (6.1) and Drug Interactions (7)].”
Source: the FDA label on DailyMed.