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GLP-1 Decoder

Trulicity Heart: How Common, How Long It Lasts, What Helps

The Trulicity label names heart rate as a reported side effect but gives no trial rate for it.

In the label
Listed, no rate given
Label term
heart rate

A quick look at Trulicity

How long it remains in the body
100%50%25%0%05 d10 d15 d20 d25 d50%25%12.5%time after the dose

The half-life is about 5 days. After 5 d, half is gone, and after five half-lives (25 d), about 3% remains.

Sources: FDA label (DailyMed).

What the Trulicity label states instead

The Trulicity label gives no rate for heart effects. Rates are given for the five side effects mentioned most often in the label.

Table 1: Adverse Reactions in the Pool of Placebo-Controlled Trials That Occurred in ≥5% of TRULICITY-Treated Adult Patients with Type 2 Diabetes Mellitus
Side effectPlaceboTrulicity 0.75 mgTrulicity 1.5 mgMore than placebo, 1.5 mg
Nausea5.3%12.4%21.1%+15.8 points
Vomiting2.3%6%12.7%+10.4 points
Diarrhea6.7%8.9%12.6%+5.9 points
Abdominal Pain4.9%6.5%9.4%+4.5 points
Decreased Appetite1.6%4.9%8.6%+7 points

Source of the label: Trulicity label (DailyMed).

Source of the label: FDA label (DailyMed).

What the Trulicity label says

For heart effects, the label provides this passage word for word:

“In adult patients, TRULICITY 0.75 mg and 1.5 mg resulted in a mean increase in heart rate (HR) of 2-4 beats per minute (bpm).”

Source of the label: FDA label (DailyMed).