Semaglutide Fatigue: Why It Happens, How Long, What Helps
Yes. Fatigue is listed in the Wegovy label at 11% on 2.4 mg. Placebo in the Wegovy trials: 5%.
- Labels that list it
- 2 of 3
- Highest rate
- 11% Wegovy
Wegovy: key facts
The half-life is about 1 week. By 7 d, half has left; following five half-lives (35 d), about 3% remains.
In STEP 1, over 68 weeks, 14.9% of body weight was reported, against 2.4% on placebo.
The maker's price page shows monthly amounts in US dollars for both list prices and self-pay offers.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
How often it happens on semaglutide, compared with placebo
The label trials list Semaglutide fatigue by dose group. In that trial, the placebo group served as the comparison group.
| Medicine and dose | Fatigue | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Wegovy 2.4 mg | 11% | 5% | +6 points | Adults with obesity or overweight (weight management) |
| Wegovy 2.4 mg | 9% | 5% | +4 points | Adults with obesity (7.2 mg dose trials) |
| Wegovy 7.2 mg | 11% | 5% | +6 points | Adults with obesity (7.2 mg dose trials) |
The source is the Wegovy label (DailyMed).
Fatigue with semaglutide compared with other GLP-1s
Each label describes trials with different groups of participants. Use this as a rough guide.
The table also includes Foundayo pill forms.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
The source is the FDA label (DailyMed).
Ozempic label information
Fatigue appears in the label here, word for word:
“Other adverse reactions with a frequency of >0.4% were associated with OZEMPIC include fatigue, dysgeusia and dizziness.”
The source is the FDA label (DailyMed).