Liraglutide Fatigue: How Common, How Long It Lasts
Yes. Fatigue is listed in the Saxenda label at 7.5% on Saxenda. Placebo in the Saxenda trials: 4.6%.
- Labels that list it
- 1 of 2
- Highest rate
- 7.5% Saxenda
Saxenda: key facts
Its half-life is about 13 hours. After 13 h, half is gone, and after five half-lives (2.7 d), about 3% remains.
The figure reported for SCALE Obesity and Prediabetes, 56 weeks was 7.4% of body weight, versus 3% on placebo.
Sources: FDA label (DailyMed).
How often this shows up with liraglutide compared with placebo
Label trials provide Liraglutide fatigue results for each dose group. Within one trial, placebo is the comparison group.
| Medicine and dose | Fatigue | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Saxenda Saxenda | 7.5% | 4.6% | +2.9 points | Adults with obesity or overweight (weight management) |
| Saxenda Saxenda | 2.1% | 0.8% | +1.3 points | Adults with obesity or overweight (weight management); the label calls this asthenia |
| Saxenda Saxenda | 4.8% | 3.2% | +1.6 points | Children 12 and older with obesity |
Source: Saxenda label (DailyMed).
Liraglutide Fatigue compared with other GLP-1s
For different groups of people, each label reports separate trials. Treat the results as a rough guide. Read it as a rough guide.
Foundayo pill forms are in the table as well.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
Taken from the FDA label (DailyMed).
Wording in the Saxenda label
Here the label mentions fatigue, word for word:
“Events of asthenia, fatigue, malaise, dysgeusia and dizziness were mainly reported within the first 12 weeks of treatment with SAXENDA and were often co-reported with”
Taken from the FDA label (DailyMed).