Zepbound Fatigue: How Common, How Long It Lasts, What Helps
Yes. In the Zepbound trials, 7% of people on 15 mg had fatigue, against 3% on placebo: about 2 times the placebo rate. It is the seventh most common side effect in that table.
- In the Zepbound label
- Yes, with a rate
- On Zepbound 15 mg
- 7%
- On placebo
- 3%
- Rank in the label table
- 7 of 16
Zepbound facts at a glance
The half-life is 5 to 6 days. After 5.5 days, half is gone, and about 3% remains after five half-lives (27.5 days).
SURMOUNT-1's 72-week result shows 20.9% of body weight versus 3.1% on placebo.
Monthly prices in US dollars include the list price and self-pay offers, each taken from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Zepbound vs placebo: how often it shows up
The label trials separate Zepbound fatigue by dose group. In that same trial, the placebo serves as the comparison group.
| Medicine and dose | Fatigue | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Zepbound 5 mg | 5% | 3% | +2 points | Adults with obesity or overweight (weight management) |
| Zepbound 10 mg | 6% | 3% | +3 points | Adults with obesity or overweight (weight management) |
| Zepbound 15 mg | 7% | 3% | +4 points | Adults with obesity or overweight (weight management) |
Source: Zepbound label (DailyMed).
How Fatigue on Zepbound compares with other GLP-1s
Each label describes its own trials, which involved different groups of people. Use this as a rough guide.
You can find Foundayo listed with the pill forms in the table.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
| Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
The cited source is FDA label (DailyMed).