Ozempic Fatigue: How Common, How Long It Lasts, What Helps
The Ozempic label names fatigue as a reported side effect but gives no trial rate for it.
- In the label
- Listed, no rate given
- Label term
- fatigue
Ozempic facts at a glance
Its half-life is about 1 week: after 7 d, half is gone, and five half-lives (35 d) leave about 3%.
In the 30-week SUSTAIN 1 trial of type 2 diabetes, weight loss was 4.7 kg, compared with 1.2 kg on placebo.
Monthly prices in US dollars include list prices and self-pay offers, each taken from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
The Ozempic label lists these instead
The Ozempic label provides no rate for fatigue. It lists these five side effects most often, along with the rates.
| Side effect | Placebo | Ozempic 0.5 mg | Ozempic 1 mg | More than placebo, 1 mg |
|---|---|---|---|---|
| Nausea | 6.1% | 15.8% | 20.3% | +14.2 points |
| Vomiting | 2.3% | 5% | 9.2% | +6.9 points |
| Diarrhea | 1.9% | 8.5% | 8.8% | +6.9 points |
| Abdominal pain | 4.6% | 7.3% | 5.7% | +1.1 points |
| Constipation | 1.5% | 5% | 3.1% | +1.6 points |
Source: Ozempic label (DailyMed).
Ozempic and other GLP-1s: Fatigue
The trials covered by each label involve different groups of people. Think of it as a rough guide.
Foundayo pill forms also appear in the table.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
| Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
Source: FDA label (DailyMed).
What the Ozempic label says
The label names fatigue here, word for word:
“Other adverse reactions with a frequency of >0.4% were associated with OZEMPIC include fatigue, dysgeusia and dizziness.”
Source: FDA label (DailyMed).