Trulicity Headache: How Common, How Long It Lasts
The Trulicity label does not list headache as a side effect. What people mean by it: pain in the head.
- In the label
- Not listed
- Most common in the label
- Nausea 21.1%
Trulicity: a quick overview
Its half-life is about 5 days. After 5 d, half is gone, and after five half-lives (25 d), about 3% remains.
Sources: FDA label (DailyMed).
What the Trulicity label lists instead
The Trulicity label does not list headache. It usually lists these five side effects.
| Side effect | Placebo | Trulicity 0.75 mg | Trulicity 1.5 mg | More than placebo, 1.5 mg |
|---|---|---|---|---|
| Nausea | 5.3% | 12.4% | 21.1% | +15.8 points |
| Vomiting | 2.3% | 6% | 12.7% | +10.4 points |
| Diarrhea | 6.7% | 8.9% | 12.6% | +5.9 points |
| Abdominal Pain | 4.9% | 6.5% | 9.4% | +4.5 points |
| Decreased Appetite | 1.6% | 4.9% | 8.6% | +7 points |
From: Trulicity label (DailyMed).
Comparing Trulicity with other GLP-1s for Headache
Each label describes its own trials, which involved different groups of people. Use it as a rough guide.
Foundayo pill forms also appear in the table.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 14% | 2.4 mg | 10% | Adults with obesity or overweight (weight management) |
 Saxenda | 13.6% | all doses | 12.6% | Adults with obesity or overweight (weight management) |
 Victoza | 11% | 1.2 mg | 7% | Adults with type 2 diabetes |
 Foundayo | 9% | 9 mg | 7% | Adults with obesity or overweight (weight management) |
| Byetta | 9% | all doses | 6% | Adults with type 2 diabetes |
 Ozempic | Not listed | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Mounjaro | Not listed | – | – | – |
 Zepbound | Not listed | – | – | – |
| Trulicity | Not listed | – | – | – |
From: Wegovy label (DailyMed), Foundayo label (DailyMed), Saxenda label (DailyMed), Victoza label (DailyMed), Byetta label (DailyMed).
Source: FDA label (DailyMed)