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GLP-1 Decoder

Trulicity Face: How Common, How Long It Lasts, What Helps

The Trulicity label does not include Face changes as a side effect. What people mean by it: a thinner or older-looking face after fast weight loss (often called Ozempic face).

In the label
Not listed
Most common in the label
Nausea 21.1%

A quick look at Trulicity

How long it remains in the body
100%50%25%0%05 d10 d15 d20 d25 d50%25%12.5%time after the dose

Its half-life is about 5 days. After 5 d, half is gone, and after five half-lives (25 d), about 3% remains.

Sources: FDA label (DailyMed).

What the Trulicity label lists instead

The Trulicity label does not include Face changes. The five side effects listed most often are these.

Table 1 presents Adverse Reactions in the Pool of Placebo-Controlled Trials That Occurred in ≥5% of TRULICITY-Treated Adult Patients with Type 2 Diabetes Mellitus
Side effectPlaceboTrulicity 0.75 mgTrulicity 1.5 mgMore than placebo, 1.5 mg
Nausea5.3%12.4%21.1%+15.8 points
Vomiting2.3%6%12.7%+10.4 points
Diarrhea6.7%8.9%12.6%+5.9 points
Abdominal Pain4.9%6.5%9.4%+4.5 points
Decreased Appetite1.6%4.9%8.6%+7 points

This information comes from the Trulicity label (DailyMed).

Source: FDA label (DailyMed).