Rybelsus Fatigue: How Common, How Long It Lasts, What Helps
Rybelsus does not list Fatigue in its label as a side effect. What people mean by it: feeling tired or low on energy. Labels also use the word asthenia (weakness).
- In the label
- Not listed
- Most common in the label
- Nausea 20%
Rybelsus facts at a glance
Its half-life is about 1 week: after 7 d, half is gone, and five half-lives leave about 3% (35 d).
Over 26 weeks in type 2 diabetes, PIONEER 1 reported 3.7 kg lost compared with 1.4 kg on placebo.
Listed monthly prices in US dollars include the list price and self-pay offers, all taken from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, Novo Nordisk pricing, Novo Nordisk.
What the Rybelsus label lists instead
Rybelsus does not list Fatigue in its label. These five are the side effects that the label reports most often.
| Side effect | Placebo | Rybelsus 7 mg | Rybelsus 14 mg | More than placebo, 14 mg |
|---|---|---|---|---|
| Nausea | 6% | 11% | 20% | +14 points |
| Abdominal Pain | 4% | 10% | 11% | +7 points |
| Diarrhea | 4% | 9% | 10% | +6 points |
| Decreased appetite | 1% | 6% | 9% | +8 points |
| Vomiting | 3% | 6% | 8% | +5 points |
Rybelsus label (DailyMed). This is the source.
Comparing Fatigue with Rybelsus and other GLP-1s
Each label covers the trials for its own drug, but those studies included different groups of people. Think of it as a rough guide.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
| Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed). These are the sources.
FDA label (DailyMed). This is the source.