Mounjaro Fatigue: How Common, How Long It Lasts, What Helps
The Mounjaro label names fatigue as a reported side effect but gives no trial rate for it.
- In the label
- Listed, no rate given
- Label term
- fatigue
Mounjaro in brief
Its half-life is about 5 days. After 5 d, half is gone, and after five half-lives (25 d), about 3% remains.
In SURPASS-1, people with type 2 diabetes lost 7.8 kg over 40 weeks, compared with 1 kg on placebo.
Monthly prices are shown in US dollars. They include the list price and self-pay offers, read from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.
What the Mounjaro label lists instead of that
The Mounjaro label gives no rate for fatigue. Rates appear for the five side effects listed most often.
| Side effect | Placebo | Mounjaro 5 mg | Mounjaro 10 mg | Mounjaro 15 mg | More than placebo, 15 mg |
|---|---|---|---|---|---|
| Nausea | 4% | 12% | 15% | 18% | +14 points |
| Diarrhea | 9% | 12% | 13% | 17% | +8 points |
| Decreased Appetite | 1% | 5% | 10% | 11% | +10 points |
| Vomiting | 2% | 5% | 5% | 9% | +7 points |
| Dyspepsia | 3% | 8% | 8% | 5% | +2 points |
From the Mounjaro label (DailyMed).
Other GLP-1s compared with Mounjaro for Fatigue
Each label reports on its own trials, which involved different groups of people. Consider it a rough guide.
The table also lists the pill forms: Foundayo.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
| Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Label sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
Source: the DailyMed FDA label.
Mounjaro labeling details
Here the label mentions fatigue, word for word:
“were similar with the exception of dysesthesia (0.7%), decreased appetite (17%), constipation (13%), vomiting (12%), abdominal pain (10%), and fatigue (10%) [see Clinical Studies (14.6)].”
Source: the DailyMed FDA label.