Saxenda Fatigue: How Common, How Long It Lasts, What Helps
Yes. In the Saxenda trials, 7.5% of people on Saxenda had fatigue, against 4.6% on placebo: a little above placebo. It is the ninth most common side effect in that table.
- In the Saxenda label
- Yes, with a rate
- On Saxenda Saxenda
- 7.5%
- On placebo
- 4.6%
- Rank in the label table
- 9 of 24
Saxenda in brief
Its half-life is about 13 hours: after 13 h, half is gone, and about 3% remains after five half-lives (2.7 d).
In the SCALE Obesity and Prediabetes, 56 weeks trial, 7.4% of body weight was reported, compared with 3% on placebo.
Sources: FDA label (DailyMed).
When comparing Saxenda with placebo, how often does it appear?
Saxenda fatigue data from label trials is organized by dose. The placebo group served as the comparison group in that same trial.
| Medicine and dose | Fatigue | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Saxenda Saxenda | 7.5% | 4.6% | +2.9 points | Adults with obesity or overweight (weight management) |
| Saxenda Saxenda | 2.1% | 0.8% | +1.3 points | For adults with obesity or overweight in weight management, the label term is asthenia |
| Saxenda Saxenda | 4.8% | 3.2% | +1.6 points | Children 12 and older with obesity |
The label source is Saxenda label (DailyMed).
Saxenda Fatigue: a comparison with other GLP-1s
Every label describes its own trials, and those studies used different groups of people. Use this as a rough guide.
Pill forms are also covered in the table: Foundayo.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
| Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
These labels are the sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
Source: FDA label (DailyMed).
Details from Saxenda's label
The label refers to fatigue here, with the exact words:
“Events of asthenia, fatigue, malaise, dysgeusia and dizziness were mainly reported within the first 12 weeks of treatment with SAXENDA and were often co-reported with”
Source: FDA label (DailyMed).