Wegovy Fatigue: How Common, How Long It Lasts, What Helps
Yes. In the Wegovy trials, 11% of people on 2.4 mg had fatigue, against 5% on placebo: about 2 times the placebo rate. It is the sixth most common side effect in that table.
- In the Wegovy label
- Yes, with a rate
- On Wegovy 2.4 mg
- 11%
- On placebo
- 5%
- Rank in the label table
- 6 of 19
A quick look at Wegovy
Its half-life is about 1 week. Half remains after 7 d, while about 3% is left following five half-lives (35 d).
In STEP 1 at 68 weeks, people lost 14.9% of body weight compared with 2.4% on placebo.
The maker's price page lists monthly price points in US dollars, including the list price and self-pay offers. Each comes from that page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
How often it appears with Wegovy compared with placebo
For each dose group, the label trials report Wegovy fatigue. Within that trial, the placebo group acts as the comparison group.
| Medicine and dose | Fatigue | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Wegovy 2.4 mg | 11% | 5% | +6 points | Adults with obesity or overweight (weight management) |
| Wegovy 2.4 mg | 9% | 5% | +4 points | Adults with obesity (7.2 mg dose trials) |
| Wegovy 7.2 mg | 11% | 5% | +6 points | Adults with obesity (7.2 mg dose trials) |
From the Wegovy label (DailyMed).
Wegovy Fatigue compared with other GLP-1s
Each label describes its own trials, and those trials involved different groups of people. Use this as a rough guide.
Pill forms are also included in the table: Foundayo.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
| Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources for the labels: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
From the FDA label (DailyMed).