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GLP-1 Decoder

Trulicity Kidney: How Common, How Long It Lasts, What Helps

The Trulicity label names acute kidney injury as a reported side effect but gives no trial rate for it.

In the label
Listed, no rate given
Label term
acute kidney injury

A quick look at Trulicity

The time it stays in the body
100%50%25%0%05 d10 d15 d20 d25 d50%25%12.5%time after the dose

Its half-life is about 5 days: after 5 d, half is gone, and about 3% remains after five half-lives (25 d).

Sources: FDA label (DailyMed).

What the Trulicity label provides instead

No rate for kidney problems appears in the Trulicity label. The label lists five side effects that occur most often and gives their rates.

In Table 1, Adverse Reactions from the Pool of Placebo-Controlled Trials That Occurred in ≥5% of TRULICITY-Treated Adult Patients with Type 2 Diabetes Mellitus are covered
Side effectPlaceboTrulicity 0.75 mgTrulicity 1.5 mgMore than placebo, 1.5 mg
Nausea5.3%12.4%21.1%+15.8 points
Vomiting2.3%6%12.7%+10.4 points
Diarrhea6.7%8.9%12.6%+5.9 points
Abdominal Pain4.9%6.5%9.4%+4.5 points
Decreased Appetite1.6%4.9%8.6%+7 points

From: the Trulicity label (DailyMed).

From: the FDA label (DailyMed).

What the Trulicity label says

Here on the label, kidney problems are mentioned in these exact words:

“There have been postmarketing reports of acute kidney injury, in some cases requiring hemodialysis, in patients treated with GLP-1 receptor agonists, including TRULICITY [see Adverse”

From: the FDA label (DailyMed).