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GLP-1 Decoder

Rybelsus Butt: How Common, How Long It Lasts, What Helps

The Rybelsus label does not list butt changes as a side effect. What people mean by it: a flatter or saggier buttock area after fast weight loss.

In the label
Not listed
Most common in the label
Nausea 20%

Rybelsus facts at a glance

How long it remains in your body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week. After 7 d, half is gone; about 3% remains after five half-lives (35 d).

Amount of weight lost in its main trial
Rybelsus (PIONEER 1)3.7 kgPlacebo1.4 kg

In PIONEER 1, people with type 2 diabetes lost 3.7 kg over 26 weeks, compared with 1.4 kg on placebo.

Cost over time
20262027$1,027.51$0List priceSelf-pay

The maker's price page supplies each monthly figure in US dollars for the list price and self-pay offers.

Sources: FDA label (DailyMed), healthsystemtracker.org, Novo Nordisk pricing, Novo Nordisk.

What does the Rybelsus label list in its place?

The Rybelsus label does not list butt changes. It lists these five side effects most often.

Table 2. Type 2 Diabetes Mellitus: Adverse Reactions in Placebo-Controlled Trials Reported in ≥5% of Semaglutide Tablets-Treated Patients
Side effectPlaceboRybelsus 7 mgRybelsus 14 mgMore than placebo, 14 mg
Nausea6%11%20%+14 points
Abdominal Pain4%10%11%+7 points
Diarrhea4%9%10%+6 points
Decreased appetite1%6%9%+8 points
Vomiting3%6%8%+5 points

Source: Rybelsus label (DailyMed).

Source: FDA label (DailyMed).