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GLP-1 Decoder

Rybelsus Hair Loss: How Common, How Long It Lasts

The Rybelsus label does not include hair loss as a side effect. What people mean by it: more hair than usual coming out. Labels call it hair loss or alopecia.

In the label
Not listed
Most common in the label
Nausea 20%

A quick look at Rybelsus

How long it remains in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

The half-life is about 1 week. After 7 d, half is gone, and after five half-lives (35 d), about 3% remains.

Main trial weight loss
Rybelsus (PIONEER 1)3.7 kgPlacebo1.4 kg

In PIONEER 1, people with type 2 diabetes lost 3.7 kg over 26 weeks, compared with 1.4 kg on placebo.

How price changes over time
20262027$1,027.51$0List priceSelf-pay

Monthly prices in US dollars include the list price and self-pay offers. Each comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, Novo Nordisk pricing, Novo Nordisk.

What the Rybelsus label lists instead

The Rybelsus label does not include hair loss. It lists five side effects most often, and these are them.

Table 2. Adverse Reactions observed in Placebo-Controlled Trials Reported in ≥5% of Semaglutide Tablets-Treated Patients with Type 2 Diabetes Mellitus
Side effectPlaceboRybelsus 7 mgRybelsus 14 mgMore than placebo, 14 mg
Nausea6%11%20%+14 points
Abdominal Pain4%10%11%+7 points
Diarrhea4%9%10%+6 points
Decreased appetite1%6%9%+8 points
Vomiting3%6%8%+5 points

The Rybelsus label (DailyMed) is the source.

Hair loss and other GLP-1s

Each label covers its own trials, and the people in each study group differ. View it as a rough guide.

Hair loss across GLP-1 labels
MedicineHighest rate in the labelDose groupPlaceboPeople in the trials
Zepbound5%5 mg1%Adults with obesity or overweight (weight management)
Foundayo5%17.2 mg2%Adults with obesity or overweight (weight management)
Wegovy3%2.4 mg1%Adults with obesity or overweight (weight management)
OzempicListed, no rate given–––
MounjaroListed, no rate given–––
TrulicityListed, no rate given–––
ByettaListed, no rate given–––
RybelsusNot listed–––
SaxendaNot listed–––
VictozaNot listed–––

Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed).

The FDA label (DailyMed) is the source.