Rybelsus Muscle Loss: How Common, How Long It Lasts
The Rybelsus label does not list muscle loss as a side effect. What people mean by it: losing muscle along with fat while losing weight.
- In the label
- Not listed
- Most common in the label
- Nausea 20%
Rybelsus in brief
The half-life is about 1 week. After 7 d, half is gone. After five half-lives (35 d), about 3% remains.
In PIONEER 1, people with type 2 diabetes lost 3.7 kg over 26 weeks, against 1.4 kg on placebo.
Prices by month in US dollars cover the list price and self-pay offers, each taken from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, Novo Nordisk pricing, Novo Nordisk.
What the Rybelsus label lists instead
The Rybelsus label does not list muscle loss. Here, you can see the five side effects listed most often.
| Side effect | Placebo | Rybelsus 7 mg | Rybelsus 14 mg | More than placebo, 14 mg |
|---|---|---|---|---|
| Nausea | 6% | 11% | 20% | +14 points |
| Abdominal Pain | 4% | 10% | 11% | +7 points |
| Diarrhea | 4% | 9% | 10% | +6 points |
| Decreased appetite | 1% | 6% | 9% | +8 points |
| Vomiting | 3% | 6% | 8% | +5 points |
Source: Rybelsus label (DailyMed).
Source details: FDA label (DailyMed).