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GLP-1 Decoder

Wegovy Body: How Common, How Long It Lasts, What Helps

Body changes do not appear on the Wegovy label as a side effect. What people mean by it: loose skin or changes in body shape after weight loss.

In the label
Not listed
Most common in the label
Nausea 44%

Wegovy in brief

How long the drug stays in your body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week. Half disappears after 7 d, while about 3% remains after five half-lives (35 d).

Main-trial weight loss
Wegovy (STEP 1)14.9%Placebo2.4%

In STEP 1, people lost 14.9% of body weight over 68 weeks, while those on placebo lost 2.4%.

Cost as time goes on
202520262027$1,349.02$0List priceSelf-pay

In US dollars, monthly figures include the list price and self-pay offers. Each comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What the Wegovy label lists instead

Body changes do not appear on the Wegovy label. It lists these five side effects more often than any others.

Table 3. Injection-treated Adults with Obesity or Overweight for Weight Reduction: Adverse Reactions (≥2% and Greater Than Placebo) with WEGOVY 2.4 mg
Side effectPlaceboWegovy 2.4 mgMore than placebo
Nausea16%44%+28 points
Diarrhea16%30%+14 points
Vomiting6%24%+18 points
Constipation11%24%+13 points
Abdominal Pain10%20%+10 points

Source: Wegovy label (DailyMed).

Source: FDA label (DailyMed).