Zepbound Hair Loss: How Common, How Long It Lasts
Yes. In the Zepbound trials, 5% of people on 5 mg had hair loss, against 1% on placebo: about 5 times the placebo rate. It is the eighth most common side effect in that table.
- In the Zepbound label
- Yes, with a rate
- On Zepbound 5 mg
- 5%
- On placebo
- 1%
- Rank in the label table
- 8 of 16
A quick look at Zepbound
The half-life of 5 to 6 days means half remains after 5.5 d. Following five half-lives (27.5 d), about 3% is left.
Weight lost during the 72-week SURMOUNT-1 trial was 20.9% of body weight, compared with 3.1% on placebo.
Monthly prices in US dollars cover list prices and self-pay offers. Each figure comes from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
How often it appears with Zepbound compared with placebo
The label trials list Zepbound hair loss for every dose group. The comparison group in that same trial is the placebo.
| Medicine and dose | Hair loss | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Zepbound 5 mg | 5% | 1% | +4 points | Adults with obesity or overweight (weight management) |
| Zepbound 10 mg | 4% | 1% | +3 points | Adults with obesity or overweight (weight management) |
| Zepbound 15 mg | 5% | 1% | +4 points | Adults with obesity or overweight (weight management) |
Source: Zepbound label (DailyMed).
Comparing Zepbound with other GLP-1s for hair loss
Each label covers its own trials, which used separate groups of people. Treat it as a rough guide.
Foundayo pill forms are also listed in the table.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
| Zepbound | 5% | 5 mg | 1% | Adults with obesity or overweight (weight management) |
 Foundayo | 5% | 17.2 mg | 2% | Adults with obesity or overweight (weight management) |
 Wegovy | 3% | 2.4 mg | 1% | Adults with obesity or overweight (weight management) |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Trulicity | Listed, no rate given | – | – | – |
| Byetta | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Saxenda | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed).
Source: FDA label (DailyMed).
What the Zepbound label states
Hair loss is mentioned in the label, with this exact wording:
“Hair loss adverse reactions in ZEPBOUND-treated patients were associated with weight reduction.”
Source: FDA label (DailyMed).