Tirzepatide Hair Loss: How Common, Why, When It Regrows
Yes. Hair loss is listed in the Zepbound label at 5% on 5 mg. Placebo in the Zepbound trials: 1%.
- Labels that list it
- 2 of 2
- Highest rate
- 5% Zepbound
A quick look at Zepbound
Its half-life is 5 to 6 days. After 5.5 d, half remains; five half-lives (27.5 d) leave about 3%.
In SURMOUNT-1 over 72 weeks, people lost 20.9% of body weight, compared with 3.1% on placebo.
Monthly prices in US dollars include the list price and self-pay offers, all taken from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Placebo compared with tirzepatide: how often does it show up?
The label trials show Tirzepatide hair loss for each dose group. The trial used placebo as its comparison group.
| Medicine and dose | Hair loss | Placebo | More than placebo | People in the trials |
|---|---|---|---|---|
| Zepbound 5 mg | 5% | 1% | +4 points | Adults with obesity or overweight (weight management) |
| Zepbound 10 mg | 4% | 1% | +3 points | Adults with obesity or overweight (weight management) |
| Zepbound 15 mg | 5% | 1% | +4 points | Adults with obesity or overweight (weight management) |
Source: Zepbound label (DailyMed).
Tirzepatide hair loss and other GLP-1s compared
Its own trials are covered by each label, with different groups of people in them. Consider it a rough guide.
The table also lists pill forms: Foundayo.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Zepbound | 5% | 5 mg | 1% | Adults with obesity or overweight (weight management) |
 Foundayo | 5% | 17.2 mg | 2% | Adults with obesity or overweight (weight management) |
 Wegovy | 3% | 2.4 mg | 1% | Adults with obesity or overweight (weight management) |
 Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Trulicity | Listed, no rate given | – | – | – |
| Byetta | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Saxenda | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed).
Source: FDA label (DailyMed).
Reports from the Zepbound label
Here is the label's exact wording about hair loss:
“Hair loss adverse reactions in ZEPBOUND-treated patients were associated with weight reduction.”
Source: FDA label (DailyMed).