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GLP-1 Decoder

Saxenda Hair Loss: How Common, How Long It Lasts, What Helps

Hair loss is not mentioned in the Saxenda label as a side effect. What people mean by it: more hair than usual coming out. Labels call it hair loss or alopecia.

In the label
Not listed
Most common in the label
Nausea 39.3%

A quick look at Saxenda

How long it remains in your body
100%50%25%0%013 h26 h39 h2.2 d2.7 d50%25%12.5%time after the dose

Half of the drug is gone after 13 h. Its half-life is about 13 hours, and five half-lives (2.7 d) leave about 3%.

Body weight lost in the main trial
Saxenda (SCALE Obesity and Prediabetes)7.4%Placebo3%

In the SCALE Obesity and Prediabetes, 56-week trial, results were 7.4% of body weight versus 3% with placebo.

Sources: FDA label (DailyMed).

What the Saxenda label lists instead

Hair loss is not mentioned in the Saxenda label. These are the five side effects listed most often.

Table 2. For SAXENDA-treated Adult Patients: Adverse Reactions Occurring in ≥2% and More Frequently than Placebo
Side effectPlaceboSaxenda SaxendaMore than placebo
Nausea13.8%39.3%+25.5 points
Diarrhea9.9%20.9%+11 points
Constipation8.5%19.4%+10.9 points
Vomiting3.9%15.7%+11.8 points
Injection Site Reaction10.5%13.9%+3.4 points

Source: Saxenda label (DailyMed).

Hair loss with Saxenda compared with other GLP-1s

Each label relies on separate trials that included different groups of people. Consider it a rough guide.

The pill forms are covered in that table as well: Foundayo.

Hair loss across GLP-1 labels
MedicineHighest rate in the labelDose groupPlaceboPeople in the trials
Zepbound5%5 mg1%Adults with obesity or overweight (weight management)
Foundayo5%17.2 mg2%Adults with obesity or overweight (weight management)
Wegovy3%2.4 mg1%Adults with obesity or overweight (weight management)
OzempicListed, no rate given–––
MounjaroListed, no rate given–––
TrulicityListed, no rate given–––
ByettaListed, no rate given–––
RybelsusNot listed–––
SaxendaNot listed–––
VictozaNot listed–––

Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed).

Source: FDA label (DailyMed)