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GLP-1 Decoder

Trulicity Sulfur Burps: How Common, How Long It Lasts

The Trulicity label does not mention sulfur burps as a side effect. What people mean by it: burps that smell or taste like rotten eggs. Labels list burping as eructation.

In the label
Not listed
Most common in the label
Nausea 21.1%

Trulicity: a quick look

How long it stays in your body
100%50%25%0%05 d10 d15 d20 d25 d50%25%12.5%time after the dose

Its half-life is about 5 days: after 5 d, half is gone, and roughly 3% remains after five half-lives (25 d).

Sources: FDA label (DailyMed).

What the Trulicity label lists instead

The Trulicity label does not mention sulfur burps. These are the five side effects listed most often.

For TRULICITY-Treated Adult Patients with Type 2 Diabetes Mellitus, Adverse Reactions in Pool of Placebo-Controlled Trials That Occurred in ≥5% (Table 1)
Side effectPlaceboTrulicity 0.75 mgTrulicity 1.5 mgMore than placebo, 1.5 mg
Nausea5.3%12.4%21.1%+15.8 points
Vomiting2.3%6%12.7%+10.4 points
Diarrhea6.7%8.9%12.6%+5.9 points
Abdominal Pain4.9%6.5%9.4%+4.5 points
Decreased Appetite1.6%4.9%8.6%+7 points

This information comes from the Trulicity label (DailyMed).

Sulfur burps seen with other GLP-1s

Each label relies on its own trials, which used different groups of people. Use this as a rough guide.

Pill forms are included in the table as well: Foundayo.

Sulfur burps across GLP-1 labels
MedicineHighest rate in the labelDose groupPlaceboPeople in the trials
Foundayo8%9 mg1%Adults with obesity or overweight (weight management)
Wegovy7%2.4 mgNot reportedAdults with obesity or overweight (weight management)
Zepbound5%10 mg1%Adults with obesity or overweight (weight management)
Saxenda4.5%all doses0.2%Adults with obesity or overweight (weight management)
OzempicNot by this name–––
RybelsusNot by this name–––
MounjaroNot by this name–––
TrulicityNot by this name–––
VictozaNot listed–––
ByettaNot by this name–––

These are the labels used as sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), and Saxenda label (DailyMed).

Source: FDA label (DailyMed).

What may explain it?

These medicines slow the rate at which your stomach empties. When food sits longer, sulfur burps may follow. This happens most often after a large or fatty meal.

Source: health.clevelandclinic.org.

What helps, step by step

  1. Cut back on sugary foods and foods that are highly processed.
  2. Eat fewer high-fiber foods right after you take your dose.
  3. Choose smaller meals, and stop eating once you feel full. These medicines slow stomach emptying.
  4. Eat slowly. Your brain needs time to sense that you are full.
  5. Go easy on fatty, greasy and sugary foods, since they often set symptoms off.
  6. If it does not ease, tell your prescriber. Another GLP-1 may be suggested, or the dose increases may be slowed.

Before taking any drugstore product, check it with the GLP-1 interactions checker.

Source: health.clevelandclinic.org.