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GLP-1 Decoder

Ozempic Sulfur Burps: How Common, How Long It Lasts

The Ozempic label does not include sulfur burps as a side effect. What people mean by it: burps that smell or taste like rotten eggs. Labels list burping as eructation.

In the label
Not listed
Most common in the label
Nausea 20.3%

Ozempic in brief

Its time in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

With a half-life of about 1 week, half disappears after 7 d. After five half-lives (35 d), about 3% remains.

Weight lost in its main trial
Ozempic (SUSTAIN 1)4.7 kgPlacebo1.2 kg

SUSTAIN 1, 30 weeks, type 2 diabetes: participants lost 4.7 kg compared with 1.2 kg on placebo.

How prices change over time
202520262027$1,027.51$0List priceSelf-pay

Monthly prices in US dollars include the list price and self-pay offers, with each price read from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What the Ozempic label lists instead

The Ozempic label does not include sulfur burps. The five side effects mentioned most often on the label are these.

Table 1. Adverse Reactions in Placebo-Controlled Trials Reported in ≥5% of OZEMPIC-Treated Patients who have Type 2 Diabetes Mellitus
Side effectPlaceboOzempic 0.5 mgOzempic 1 mgMore than placebo, 1 mg
Nausea6.1%15.8%20.3%+14.2 points
Vomiting2.3%5%9.2%+6.9 points
Diarrhea1.9%8.5%8.8%+6.9 points
Abdominal pain4.6%7.3%5.7%+1.1 points
Constipation1.5%5%3.1%+1.6 points

Source: Ozempic label (DailyMed).

Sulfur burps with other GLP-1s

Each label covers its own trials, which involve different groups of people. Consider this a rough guide.

Pill forms are also included in the table: Foundayo.

Sulfur burps across GLP-1 labels
MedicineHighest rate in the labelDose groupPlaceboPeople in the trials
Foundayo8%9 mg1%Adults with obesity or overweight (weight management)
Wegovy7%2.4 mgNot reportedAdults with obesity or overweight (weight management)
Zepbound5%10 mg1%Adults with obesity or overweight (weight management)
Saxenda4.5%all doses0.2%Adults with obesity or overweight (weight management)
OzempicNot by this name–––
RybelsusNot by this name–––
MounjaroNot by this name–––
TrulicityNot by this name–––
VictozaNot listed–––
ByettaNot by this name–––

Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Saxenda label (DailyMed).

Source: FDA label (DailyMed).

What could explain it?

These medicines slow how quickly the stomach empties. Because food sits longer, sulfur burps can show up, most of all after a big or fatty meal.

Source: health.clevelandclinic.org.

What helps, step by step

  1. Reduce how many sugary and highly processed foods you eat.
  2. Right after your dose, go easy on foods high in fiber.
  3. Eat smaller meals, and stop once you feel full. These medicines slow down how fast your stomach empties.
  4. Eat slowly. Time passes before your brain notices that you are full.
  5. Cut back on fatty, greasy and sugary foods, because these often cause symptoms.
  6. If the problem does not ease, tell your prescriber. Your prescriber may increase the dose more slowly or suggest a different GLP-1.

Before taking anything bought at the drugstore, use the GLP-1 interactions checker to check for interactions.

Source: health.clevelandclinic.org.