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GLP-1 Decoder

Semaglutide Dizziness: How Common, How Long It Lasts

Yes. Dizziness is listed in the Wegovy label at 8% on 2.4 mg. Placebo in the Wegovy trials: 4%.

Labels that list it
2 of 3
Highest rate
8% Wegovy

Wegovy in brief

How long the body keeps it
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

The half-life is about 1 week. After 7 d, half is gone, while about 3% remains after five half-lives (35 d).

Body weight lost in the main trial
Wegovy (STEP 1)14.9%Placebo2.4%

At STEP 1 over 68 weeks, the figure was 14.9% of body weight, versus 2.4% on placebo.

Costs over time
202520262027$1,349.02$0List priceSelf-pay

The maker's price page gives monthly price points in US dollars for both list prices and self-pay offers.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

How often it happens with semaglutide compared with placebo

Semaglutide dizziness is reported in the label trials by dose group. The same trial uses placebo as its comparison group.

Dizziness in the semaglutide labels
Medicine and doseDizzinessPlaceboMore than placeboPeople in the trials
Wegovy 2.4 mg8%4%+4 pointsAdults with obesity or overweight (weight management)
Wegovy 2.4 mg5%1%+4 pointsAdults with obesity (7.2 mg dose trials)
Wegovy 7.2 mg6%1%+5 pointsAdults with obesity (7.2 mg dose trials)
Wegovy 2.4 mg8%3%+5 pointsChildren 12 and older with obesity

Source: Wegovy label (DailyMed).

Dizziness rates: semaglutide compared with other GLP-1s

Each label describes its own trials, and the trial groups vary. Use this as a rough guide.

Dizziness across GLP-1 labels
MedicineHighest rate in the labelDose groupPlaceboPeople in the trials
Byetta9%all doses6%Adults with type 2 diabetes
Wegovy8%2.4 mg4%Adults with obesity or overweight (weight management)
Saxenda6.9%all doses5%Adults with obesity or overweight (weight management)
Zepbound5%10 mg2%Adults with obesity or overweight (weight management)
OzempicListed, no rate given–––
FoundayoListed, no rate given–––
RybelsusNot listed–––
MounjaroNot listed–––
TrulicityNot listed–––
VictozaNot listed–––

Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).

Source: FDA label on DailyMed.

Ozempic label words

Dizziness appears in the label word for word:

“Other adverse reactions with a frequency of >0.4% were associated with OZEMPIC include fatigue, dysgeusia and dizziness.”

Source: FDA label on DailyMed.