Semaglutide Allergic Reaction: How Common, How Long It Lasts
The semaglutide labels name hypersensitivity as a reported side effect but give no trial rate for it.
- In the label
- Listed, no rate given
- Label term
- hypersensitivity
Wegovy details at a glance
The half-life is about 1 week: after 7 d, half is gone, and after five half-lives (35 d), about 3% remains.
At 68 weeks, STEP 1 reported 14.9% of body weight, compared with 2.4% on placebo.
In US dollars, monthly figures cover the list price and self-pay offers. Each figure comes from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
What the Ozempic label lists instead
The Ozempic label gives no rate for allergic reaction. Five side effects appear most often, with a rate given for each.
| Side effect | Placebo | Ozempic 0.5 mg | Ozempic 1 mg | More than placebo, 1 mg |
|---|---|---|---|---|
| Nausea | 6.1% | 15.8% | 20.3% | +14.2 points |
| Vomiting | 2.3% | 5% | 9.2% | +6.9 points |
| Diarrhea | 1.9% | 8.5% | 8.8% | +6.9 points |
| Abdominal pain | 4.6% | 7.3% | 5.7% | +1.1 points |
| Constipation | 1.5% | 5% | 3.1% | +1.6 points |
Source: Ozempic label (DailyMed).
Allergic reaction involving other GLP-1s
Labels describe separate trials involving different groups of people. Treat this information as a rough guide. For a rough guide, use it.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Zepbound | 5% | 5 mg | 3% | Adults with obesity or overweight (weight management) |
 Ozempic | Listed, no rate given | – | – | – |
 Wegovy | Listed, no rate given | – | – | – |
 Rybelsus | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Foundayo | Listed, no rate given | – | – | – |
 Trulicity | Listed, no rate given | – | – | – |
 Saxenda | Listed, no rate given | – | – | – |
 Victoza | Listed, no rate given | – | – | – |
| Byetta | Listed, no rate given | – | – | – |
Source: Zepbound label (DailyMed).
Source: FDA label (DailyMed).
What the Ozempic label says
The label mentions allergic reaction in these exact words:
“Serious hypersensitivity reactions (e.g., anaphylaxis, angioedema) have been reported in patients treated with OZEMPIC.”
Source: FDA label (DailyMed).