Skip to content
GLP-1 Decoder

Semaglutide Butt: How Common, How Long It Lasts, What Helps

The semaglutide labels do not list butt changes as a side effect. What people mean by it: a flatter or saggier buttock area after fast weight loss.

In the label
Not listed
Most common in the label
Nausea 20.3%

Wegovy, in brief

How long it remains in your body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

The half-life is about 1 week. Half clears after 7 d, and about 3% remains by five half-lives (35 d).

Weight loss in its main trial
Wegovy (STEP 1)14.9%Placebo2.4%

In STEP 1 over 68 weeks, 14.9% of body weight was lost, compared with 2.4% on placebo.

Costs over time
202520262027$1,349.02$0List priceSelf-pay

Monthly prices are listed in US dollars. They include the list price and self-pay offers, with each figure taken from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What the Ozempic label includes instead

Butt changes do not appear on Ozempic's label. These are the five side effects listed most often.

Table 1. Adverse Reactions in Placebo-Controlled Trials Reported in ≥5% of OZEMPIC-Treated Patients with Type 2 Diabetes Mellitus
Side effectPlaceboOzempic 0.5 mgOzempic 1 mgMore than placebo, 1 mg
Nausea6.1%15.8%20.3%+14.2 points
Vomiting2.3%5%9.2%+6.9 points
Diarrhea1.9%8.5%8.8%+6.9 points
Abdominal pain4.6%7.3%5.7%+1.1 points
Constipation1.5%5%3.1%+1.6 points

Source: Ozempic label (DailyMed).

Source: FDA label (DailyMed).