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GLP-1 Decoder

Saxenda Face: How Common, How Long It Lasts, What Helps

The Saxenda label does not list face changes as a side effect. What people mean by it: a thinner or older-looking face after fast weight loss (often called Ozempic face).

In the label
Not listed
Most common in the label
Nausea 39.3%

A quick look at Saxenda

Inside the body: how long it stays
100%50%25%0%013 h26 h39 h2.2 d2.7 d50%25%12.5%time after the dose

Its half-life is about 13 hours: after 13 h, half is gone. At five half-lives, or 2.7 d, about 3% remains.

Weight loss during its main trial
Saxenda (SCALE Obesity and Prediabetes)7.4%Placebo3%

The results for SCALE Obesity and Prediabetes, 56 weeks showed 7.4% body weight loss, against 3% on placebo.

Sources: FDA label (DailyMed).

What the Saxenda label says instead

The Saxenda label does not list face changes. It does list these five side effects most often.

Table 2. For SAXENDA-treated Adult Patients, Adverse Reactions Occurring in ≥2% appeared More Frequently than Placebo
Side effectPlaceboSaxenda SaxendaMore than placebo
Nausea13.8%39.3%+25.5 points
Diarrhea9.9%20.9%+11 points
Constipation8.5%19.4%+10.9 points
Vomiting3.9%15.7%+11.8 points
Injection Site Reaction10.5%13.9%+3.4 points

Source: Saxenda label (DailyMed).

Source: FDA label (DailyMed).