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GLP-1 Decoder

Ozempic Face Before and After: What Changes, Why

The Ozempic label does not list face changes as a side effect. What people mean by it: a thinner or older-looking face after fast weight loss (often called Ozempic face).

In the label
Not listed
Most common in the label
Nausea 20.3%

A quick look at Ozempic

How long it remains in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week. After 7 d, half is gone, and after five half-lives (35 d), about 3% remains.

Weight loss in its main trial
Ozempic (SUSTAIN 1)4.7 kgPlacebo1.2 kg

Participants with type 2 diabetes in the 30-week SUSTAIN 1 trial lost 4.7 kg, compared with 1.2 kg on placebo.

Costs over time
202520262027$1,027.51$0List priceSelf-pay

Monthly figures in US dollars cover the list price and self-pay offers, with each amount taken from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

Instead, what the Ozempic label shows

The Ozempic label does not list face changes. The five side effects listed most often are these.

Table 1. Placebo-Controlled Trials Reported: Adverse Reactions in ≥5% of OZEMPIC-Treated Patients with Type 2 Diabetes Mellitus
Side effectPlaceboOzempic 0.5 mgOzempic 1 mgMore than placebo, 1 mg
Nausea6.1%15.8%20.3%+14.2 points
Vomiting2.3%5%9.2%+6.9 points
Diarrhea1.9%8.5%8.8%+6.9 points
Abdominal pain4.6%7.3%5.7%+1.1 points
Constipation1.5%5%3.1%+1.6 points

Taken from: Ozempic label (DailyMed).

Source: FDA label (DailyMed).