Ozempic and Sleepiness: Is Tiredness a Side Effect?
The Ozempic label names fatigue as a reported side effect but gives no trial rate for it.
- In the label
- Listed, no rate given
- Label term
- fatigue
Ozempic in brief
Its half-life is about 1 week: by 7 d, half is gone, and about 3% remains after five half-lives (35 d).
SUSTAIN 1 studied type 2 diabetes over 30 weeks: 4.7 kg lost, compared with 1.2 kg for people on placebo.
Monthly figures in US dollars: the list price and the self-pay offers, with each one read from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
What the Ozempic label lists instead
For fatigue, the Ozempic label gives no rate. It lists the five side effects it reports most often, and gives a rate for each.
| Side effect | Placebo | Ozempic 0.5 mg | Ozempic 1 mg | More than placebo, 1 mg |
|---|---|---|---|---|
| Nausea | 6.1% | 15.8% | 20.3% | +14.2 points |
| Vomiting | 2.3% | 5% | 9.2% | +6.9 points |
| Diarrhea | 1.9% | 8.5% | 8.8% | +6.9 points |
| Abdominal pain | 4.6% | 7.3% | 5.7% | +1.1 points |
| Constipation | 1.5% | 5% | 3.1% | +1.6 points |
Taken from the Ozempic label (DailyMed).
How Ozempic sleepiness compares with other GLP-1s
Each label covers its own trials, and those trials used different groups of people. Use it as a rough guide.
The pill forms are in the table too: Foundayo.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 11% | 2.4 mg | 5% | Adults with obesity or overweight (weight management) |
 Foundayo | 9% | 17.2 mg | 4% | Adults with obesity or overweight (weight management) |
 Saxenda | 7.5% | all doses | 4.6% | Adults with obesity or overweight (weight management) |
 Zepbound | 7% | 15 mg | 3% | Adults with obesity or overweight (weight management) |
 Trulicity | 5.6% | 1.5 mg | 2.6% | Adults with type 2 diabetes |
| Byetta | 4% | all doses | 2% | Adults with type 2 diabetes |
| Ozempic | Listed, no rate given | – | – | – |
 Mounjaro | Listed, no rate given | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Zepbound label (DailyMed), Foundayo label (DailyMed), Trulicity label (DailyMed), Saxenda label (DailyMed), Byetta label (DailyMed).
Source: FDA label (DailyMed).
What the Ozempic label says
The label lists fatigue here, word for word:
“Other adverse reactions with a frequency of >0.4% were associated with OZEMPIC include fatigue, dysgeusia and dizziness.”
Source: FDA label (DailyMed).