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GLP-1 Decoder

Zepbound Butt: How Common, How Long It Lasts, What Helps

Butt changes are not listed on the Zepbound label as a side effect. What people mean by it: a flatter or saggier buttock area after fast weight loss.

In the label
Not listed
Most common in the label
Nausea 29%

Zepbound in brief

How long it remains in your body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

With a half-life of 5 to 6 days, half disappears after 5.5 d. After five half-lives (27.5 d), about 3% is still present.

Body weight loss during its main trial
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1, participants lost 20.9% of body weight over 72 weeks, compared with 3.1% on placebo.

Cost over time
202420252026$1,086.37$0List priceSelf-pay

Monthly prices in US dollars include the list price and self-pay offers, with each taken from the maker's price page.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.

What the Zepbound label includes instead

Butt changes are not listed on the Zepbound label. These are the five side effects listed most often.

For ZEPBOUND-Treated Adults with Obesity or Overweight, Table 1 shows Adverse Reactions (≥2% and Greater than Placebo) from Weight Reduction and Long-term Maintenance Trials (Study 1 and Study 2)
Side effectPlaceboZepbound 5 mgZepbound 10 mgZepbound 15 mgMore than placebo, 15 mg
Nausea8%25%29%28%+20 points
Diarrhea8%19%21%23%+15 points
Constipation5%17%14%11%+6 points
Vomiting2%8%11%13%+11 points
Abdominal Pain5%9%9%10%+5 points

Source: Zepbound label (DailyMed).

Source details: Label information from FDA (DailyMed).