Zepbound Face: How Common, How Long It Lasts, What Helps
The Zepbound label does not list face changes as a side effect. What people mean by it: a thinner or older-looking face after fast weight loss (often called Ozempic face).
- In the label
- Not listed
- Most common in the label
- Nausea 29%
Zepbound in brief
The half-life is 5 to 6 days. After 5.5 d, half is gone, and about 3% remains after five half-lives (27.5 d).
In SURMOUNT-1 at 72 weeks, results were 20.9% of body weight versus 3.1% on placebo.
Monthly US dollar price points include list prices and self-pay offers. Each comes from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
What the Zepbound label lists instead
The Zepbound label does not list face changes. These are the five side effects the label lists as most common.
| Side effect | Placebo | Zepbound 5 mg | Zepbound 10 mg | Zepbound 15 mg | More than placebo, 15 mg |
|---|---|---|---|---|---|
| Nausea | 8% | 25% | 29% | 28% | +20 points |
| Diarrhea | 8% | 19% | 21% | 23% | +15 points |
| Constipation | 5% | 17% | 14% | 11% | +6 points |
| Vomiting | 2% | 8% | 11% | 13% | +11 points |
| Abdominal Pain | 5% | 9% | 9% | 10% | +5 points |
Taken from the Zepbound label (DailyMed).
Taken from the FDA label (DailyMed).