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GLP-1 Decoder

GLP-1 Muscle Loss: How Common, How Long It Lasts, What Helps

The GLP-1 medicines labels do not list muscle loss as a side effect. What people mean by it: losing muscle along with fat while losing weight.

In the label
Not listed
Most common in the label
Nausea 20.3%

Source: FDA label (DailyMed).

Quick look at half-life and weight loss

How long each stays inside the body
Wegovy7 dOzempic7 dRybelsus7 dZepbound5.5 dMounjaro5 dTrulicity5 dFoundayo1.6 dSaxenda0.5 dVictoza0.5 dByetta0.1 d

The time needed to clear half a dose, measured in days, is the half-life. Each FDA label lists the information in section 12.3.

Body weight lost in the main weight trial for each medicine
Zepbound20.9%Wegovy14.9%Foundayo11.1%Saxenda7.4%

Percentage of body weight. Trials, doses, and lengths vary, so compare each result with its own placebo on its page.

Sources (10)

FDA label (DailyMed) 1 2 3 4 5 6 7 8 9 10.