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GLP-1 Decoder

Liraglutide Muscle Loss: How Common, How Long It Lasts

The liraglutide labels do not list muscle loss as a side effect. What people mean by it: losing muscle along with fat while losing weight.

In the label
Not listed
Most common in the label
Nausea 20%

A brief look at Saxenda

How long it stays in your body
100%50%25%0%013 h26 h39 h2.2 d2.7 d50%25%12.5%time after the dose

The half-life is about 13 hours. Once 13 h pass, half is gone. Five half-lives (2.7 d) leave about 3%.

Main trial weight loss
Saxenda (SCALE Obesity and Prediabetes)7.4%Placebo3%

The result from SCALE Obesity and Prediabetes, 56 weeks, was 7.4% of body weight, compared with 3% on placebo.

Information from FDA label (DailyMed).

What the Victoza label lists instead

The Victoza label does not list muscle loss. These five side effects appear most often on the label.

Table 1. These adverse reactions were reported by ≥5% of Adult Patients Treated with VICTOZA for Type 2 Diabetes Mellitus
Side effectPlaceboVictoza 1.2 mgVictoza 1.8 mgMore than placebo, 1.8 mg
Nausea5%18%20%+15 points
Diarrhea4%10%12%+8 points
Headache7%11%10%+3 points
Nasopharyngitis8%9%10%+2 points
Decreased appetite1%10%9%+8 points

Source: Victoza label (DailyMed).

Source: FDA label (DailyMed).