Wegovy and Insulin: Is It Safe? Label, Studies
Low blood sugar is more likely with insulin; your doctor may lower the insulin dose.
- Verdict
- With care, using it is fine
- Label says
- Listed interaction
Check a GLP-1 interaction
Wegovy in brief
Its half-life is about 1 week: after 7 d, half is gone, and about 3% remains following five half-lives (35 d).
At 68 weeks in STEP 1: 14.9% of body weight, compared with 2.4% on placebo.
Monthly prices in US dollars include the list price and self-pay offers. Each figure comes from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
Wegovy and insulin: the verdict
With care, using it is fine
Wegovy label wording for the drug interactions section, word for word:
“The risk of hypoglycemia is increased when WEGOVY is used concomitantly with insulin or insulin secretagogues (e.g., sulfonylureas). The addition of WEGOVY in patients treated”
The source is the DailyMed FDA label.
What the Label says
The Wegovy label contains the relevant lines on insulin.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | Low blood sugar is more likely when it is used with insulin or a sulfonylurea. Examples include glipizide or glimepiride. Your doctor may reduce those doses. |
Source: Wegovy label (DailyMed).
What the studies show
- Label interaction with Insulin or sulfonylureas
The source is the DailyMed FDA label.
The practical rule
- Check your blood sugar more often when you start or change doses.
- During the first weeks and following every dose increase, monitor your blood sugar more often.
The source is the DailyMed FDA label.
Insulin with other GLP-1s
For this issue, we reviewed the drug interaction section of each label.
| Medicine | Insulin in the label | Verdict | Page |
|---|---|---|---|
 Ozempic | Named in the label | With care, using it is fine | Read the answer |
| Wegovy | Named in the label | With care, using it is fine | Not listed |
 Rybelsus | Named in the label | Not listed | Not listed |
 Mounjaro | Named in the label | With care, using it is fine | Read the answer |
 Zepbound | Named in the label | With care, using it is fine | Read the answer |
 Foundayo | Named in the label | Not listed | Not listed |
 Trulicity | Named in the label | With care, using it is fine | Read the answer |
 Saxenda | Named in the label | Not listed | Not listed |
 Victoza | Named in the label | With care, using it is fine | Read the answer |
| Byetta | Named in the label | Not listed | Not listed |
The source is the DailyMed FDA label.