Mounjaro and Insulin: Is It Safe? Label, Studies
Low blood sugar is more likely with insulin; your doctor may lower the insulin dose.
- Verdict
- Fine with care
- Label says
- Listed interaction
Check a GLP-1 interaction
A quick look at Mounjaro
The half-life runs about 5 days. After 5 d, half is gone; about 3% is left at five half-lives (25 d).
In SURPASS-1, people with type 2 diabetes lost 7.8 kg over 40 weeks, compared with 1 kg on placebo.
Monthly prices in US dollars cover the list price and self-pay offers, each taken from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.
Mounjaro and insulin: the verdict
Fine with care
The Mounjaro label's drug interactions section uses these exact words:
“When initiating MOUNJARO, consider reducing the dose of concomitantly administered insulin secretagogues (e.g., sulfonylureas) or insulin to reduce the risk of hypoglycemia [see Warnings and”
The source is the FDA DailyMed label.
Mounjaro's label: what it says
Insulin is covered by these Mounjaro label lines.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | Combining it with insulin or a sulfonylurea, for example glipizide or glimepiride, raises the chance of low blood sugar. Your doctor may then reduce those doses. |
This information comes from the Mounjaro label (DailyMed).
What the studies show
- Insulin or sulfonylureas interaction noted in the label
The source is the FDA DailyMed label.
The practical rule
- Start testing your blood sugar more often when you begin treatment or change doses.
- In the first weeks and after each dose increase, check blood sugar more often.
The source is the FDA DailyMed label.
Insulin with other GLP-1s
For the same issue, the drug interaction section of every label was checked.
| Medicine | Insulin in the label | Verdict | Page |
|---|---|---|---|
 Ozempic | Named in the label | Fine with care | Read the answer |
 Wegovy | Named in the label | Fine with care | Read the answer |
 Rybelsus | Named in the label | Not listed | Not listed |
| Mounjaro | Named in the label | Fine with care | Not listed |
 Zepbound | Named in the label | Fine with care | Read the answer |
 Foundayo | Named in the label | Not listed | Not listed |
 Trulicity | Named in the label | Fine with care | Read the answer |
 Saxenda | Named in the label | Not listed | Not listed |
 Victoza | Named in the label | Fine with care | Read the answer |
| Byetta | Named in the label | Not listed | Not listed |
The source is the FDA DailyMed label.