Tirzepatide and Insulin: Is It Safe? Label, Studies
Low blood sugar is more likely with insulin; your doctor may lower the insulin dose.
- Verdict
- Fine with care
- Label says
- Listed interaction
Check a GLP-1 interaction
Zepbound, in brief
The half-life is 5 to 6 days. Half clears by 5.5 d, and about 3% stays after five half-lives (27.5 d).
The 72-week SURMOUNT-1 result was 20.9% of body weight versus 3.1% on placebo.
Monthly prices in US dollars include the list price and self-pay offers, all taken from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Tirzepatide and insulin: the verdict
Fine with care
The Mounjaro label states this word for word under drug interactions:
“When initiating MOUNJARO, consider reducing the dose of concomitantly administered insulin secretagogues (e.g., sulfonylureas) or insulin to reduce the risk of hypoglycemia [see Warnings and”
The FDA label (DailyMed) says this.
What tirzepatide's label states
The Mounjaro label includes these statements about insulin:
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | Low blood sugar is more likely when you take it together with insulin or a sulfonylurea (for example glipizide or glimepiride). Your doctor may reduce those doses. |
This comes from the Mounjaro label (DailyMed).
What the studies show
- details about insulin or sulfonylurea interactions in the
- details about insulin or sulfonylurea interactions in the
The FDA label (DailyMed) says this.
The practical rule
- When you start or change doses, check your blood sugar more often and learn the signs of low blood sugar.
- During your first weeks and after each dose increase, check your blood sugar more often.
The FDA label (DailyMed) says this.
Insulin with other GLP-1s
We reviewed every label's drug interaction section for this.
| Medicine | Insulin in the label | Verdict | Page |
|---|---|---|---|
 Ozempic | Named in the label | Fine with care | Read the answer |
 Wegovy | Named in the label | Fine with care | Read the answer |
 Rybelsus | Named in the label | Not listed | Not listed |
 Mounjaro | Named in the label | Fine with care | Read the answer |
 Zepbound | Named in the label | Fine with care | Read the answer |
 Foundayo | Named in the label | Not listed | Not listed |
 Trulicity | Named in the label | Fine with care | Read the answer |
 Saxenda | Named in the label | Not listed | Not listed |
 Victoza | Named in the label | Fine with care | Read the answer |
| Byetta | Named in the label | Not listed | Not listed |
The FDA label (DailyMed) says this.