Trulicity and Insulin: Is It Safe? Label, Studies
Low blood sugar is more likely with insulin; your doctor may lower the insulin dose.
- Verdict
- Fine with care
- Label says
- Listed interaction
Check a GLP-1 interaction
Trulicity: a quick overview
Its half-life is about 5 days: after 5 d, half is gone, and after five half-lives (25 d), about 3% remains.
Sources: FDA label (DailyMed).
Trulicity and insulin: the verdict
Fine with care
The Trulicity label's drug interactions section states this word for word:
“When initiating TRULICITY, consider reducing the dose of concomitantly administered insulin secretagogues (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia [see Warnings”
Source: FDA label (DailyMed).
Statements from the Trulicity label
Regarding insulin, these Trulicity label lines apply.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | Taking this medicine with insulin or a sulfonylurea such as glipizide or glimepiride raises the risk of low blood sugar. |
Source: Trulicity label (DailyMed).
What the studies show
- Insulin or sulfonylurea interaction noted in the label
Source: FDA label (DailyMed).
The practical rule
- Check your blood sugar more often when you start treatment or change doses.
- Check your blood sugar more often during the first weeks and after every dose increase.
Source: FDA label (DailyMed).
Insulin with other GLP-1s
Each label's drug interaction section was checked for the same information.
| Medicine | Insulin in the label | Verdict | Page |
|---|---|---|---|
 Ozempic | Named in the label | Fine with care | Read the answer |
 Wegovy | Named in the label | Fine with care | Read the answer |
 Rybelsus | Named in the label | Not listed | Not listed |
 Mounjaro | Named in the label | Fine with care | Read the answer |
 Zepbound | Named in the label | Fine with care | Read the answer |
 Foundayo | Named in the label | Not listed | Not listed |
| Trulicity | Named in the label | Fine with care | Not listed |
 Saxenda | Named in the label | Not listed | Not listed |
 Victoza | Named in the label | Fine with care | Read the answer |
| Byetta | Named in the label | Not listed | Not listed |
Source: FDA label (DailyMed).