Wegovy and Vyvanse: Is It Safe? Label, Studies
No interaction is listed, but both can curb appetite; ask your prescriber before combining.
- Verdict
- Ask your prescriber first
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Wegovy in brief
Its half-life is about 1 week: after 7 d, half is gone, while about 3% remains once five half-lives (35 d) have passed
In STEP 1, which lasted 68 weeks, body weight fell 14.9%, compared with 2.4% on placebo
Each month’s figures in US dollars cover the list price and self-pay offers, based on the maker's price page
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
Wegovy and Vyvanse: the verdict
Ask your prescriber first
The Wegovy label gives this passage word for word in its drug interactions section:
“WEGOVY causes a delay of gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. In clinical pharmacology trials”
The source is the DailyMed FDA label
What the Wegovy label says
The Wegovy label does not name Vyvanse. These lines still cover it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | The delay in stomach emptying can affect how other pills are absorbed by your body |
Source: Wegovy label (DailyMed).
What the studies show
- Drug Interactions section label section
- label limit stating that it is not for weight loss
The source is the DailyMed FDA label
The practical rule
- Let your prescriber know that you take both, and report a racing heart or eating very little
- Tell the person who prescribes your GLP-1 about every pill you take, including this one.
- Ask your pharmacist whether your pills need to maintain a steady blood level. When you start or raise the dose, those may need to be checked.
The source is the DailyMed FDA label
Vyvanse with other GLP-1s
None of the 10 GLP-1 labels mentions Vyvanse in its drug interaction section. Each label gives the same general caution about swallowed pills, so the answer remains the same for this entire group.
The source is the DailyMed FDA label