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GLP-1 Decoder

Liraglutide Face: How Common, How Long It Lasts, What Helps

The liraglutide labels do not list face changes as a side effect. What people mean by it: a thinner or older-looking face after fast weight loss (often called Ozempic face).

In the label
Not listed
Most common in the label
Nausea 20%

A quick look at Saxenda

Time in your body
100%50%25%0%013 h26 h39 h2.2 d2.7 d50%25%12.5%time after the dose

About 13 hours is the half-life. At 13 h, half has left, while five half-lives (2.7 d) leaves about 3%.

Main trial weight loss
Saxenda (SCALE Obesity and Prediabetes)7.4%Placebo3%

The SCALE Obesity and Prediabetes, 56 weeks result was 7.4% of body weight, versus 3% on placebo.

Sources: FDA label (DailyMed).

What the Victoza label lists instead

The Victoza label does not include Face changes. The label lists these five side effects most often.

Table 1. Adult Patients Treated with VICTOZA for Type 2 Diabetes Mellitus: adverse reactions reported in ≥5%
Side effectPlaceboVictoza 1.2 mgVictoza 1.8 mgMore than placebo, 1.8 mg
Nausea5%18%20%+15 points
Diarrhea4%10%12%+8 points
Headache7%11%10%+3 points
Nasopharyngitis8%9%10%+2 points
Decreased appetite1%10%9%+8 points

Source: Victoza label (DailyMed).

Source: FDA label (DailyMed).