Mounjaro and Jardiance: Is It Safe? Label, Studies
Often prescribed together; take extra care with fluids and meals when you are sick or eating little.
- Verdict
- Fine with care
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Mounjaro: a quick overview
Half-life about 5 days: after 5 d, half is gone, and after five half-lives (25 d), about 3% remains.
SURPASS-1, 40 weeks, type 2 diabetes: participants lost 7.8 kg compared with 1 kg on placebo.
Price points each month in US dollars cover list price and self-pay offers. Each figure comes from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.
Mounjaro and Jardiance: the verdict
Fine with care
From the Mounjaro label's drug interactions section, here are the exact words:
“MOUNJARO delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. Caution should be exercised when oral medications”
Source: the DailyMed FDA label.
What the Mounjaro label says
The Mounjaro label does not name Jardiance (empagliflozin). These lines also apply to it. The lines here are the ones that still apply to it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | Combining it with insulin or medicines in the sulfonylurea group, including glipizide or glimepiride, raises the chance of low blood sugar. The doctor may reduce the doses of these medicines. |
| Oral medicines | Pills absorbed differently | By slowing stomach emptying, it can change how the body takes in other pills. |
Source: Mounjaro label (DailyMed).
What the studies show
- clinical trials involving use with SGLT2 inhibitors
- Acute Kidney Injury Due to Volume Depletion: the Label warning
- reduced caloric intake can trigger ketoacidosis
- Volume depletion can trigger ketoacidosis
Source: the DailyMed FDA label.
The practical rule
- If you cannot keep food or fluids down, call your doctor on the same day.
- Let the person who prescribes your GLP-1 know about all the pills you take, including this one.
- Ask your pharmacist if any of your pills need a steady blood level. When you start treatment or raise the dose, those pills may need to be checked. You may need to have those checked when you start the medicine or raise the dose.
- During the first weeks and after each dose increase, test your blood sugar more often.
Source: the DailyMed FDA label.
Jardiance with other GLP-1s
None of the 10 GLP-1 labels names Jardiance (empagliflozin) in the drug interaction section. Every medicine in this class has the same general warning about pills you swallow, so the answer does not change across the class.
It applies equally to Ozempic, Rybelsus, Trulicity, Victoza. The question is the same for each.
Source: the DailyMed FDA label.