Mounjaro and Other Medications: Is It Safe? Label, Studies
Mounjaro slows stomach emptying, which can change how pills work; check each one with a pharmacist.
- Verdict
- Fine with care
- Label interaction lines
- 4
Check a GLP-1 interaction
A quick look at Mounjaro
The half-life is about 5 days: after 5 d, half is gone, and about 3% remains after five half-lives (25 d).
During the 40-week SURPASS-1 trial in type 2 diabetes, weight loss was 7.8 kg, compared with 1 kg on placebo.
Monthly US-dollar price points: the maker's price page lists the list price and self-pay offers.
Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.
Mounjaro and other medications: the verdict
Fine with care
The Mounjaro label states that it slows stomach emptying, which can affect how your body absorbs other medicines taken by mouth. You need to watch medicines more closely when small changes in their levels matter.
The Mounjaro label: what it states
Every interaction listed in the Mounjaro label. Questions about medicines taken by mouth besides these fall under one of these.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | When you take this medicine with insulin or a sulfonylurea, for example glipizide or glimepiride, your chance of low blood sugar goes up. Your doctor may reduce the amounts. |
| Oral medicines | Pills absorbed differently | This medicine slows stomach emptying, which can affect how your body absorbs other pills. |
| Birth control pills | Birth control pills may work less well | The pills you take for birth control may work less well for a while. After you start and after every dose increase, choose a non-oral form of birth control, or add a barrier method. |
| Warfarin and narrow-range drugs | Blood thinner levels need checking | Certain medicines, including warfarin, need closer monitoring because even small changes in their levels are important. |
Source: Mounjaro label (DailyMed).
What the studies show
- Label interaction involving oral medicines
- Label interaction involving warfarin and narrow-range drugs
- Label interaction involving birth control pills
Source: FDA label at DailyMed.
The practical rule
Show your pharmacist every medicine you take, including anything bought without a prescription.
Source: FDA label at DailyMed.
Other medications with other GLP-1s
In its drug interaction section, none of the 10 GLP-1 labels lists other medicines taken by mouth. All of them carry one general caution for swallowed pills, so the answer stays the same across the class.
Source: FDA label at DailyMed.