Mounjaro and Wellbutrin: Is It Safe? Label, Studies
No interaction is listed; ask your pharmacist, since GLP-1 medicines can change how pills absorb.
- Verdict
- Speak with your prescriber first
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Mounjaro: key facts
Its half-life is about 5 days: after 5 d, half is gone, and about 3% remains after five half-lives (25 d).
In SURPASS-1, people with type 2 diabetes lost 7.8 kg over 40 weeks, compared with 1 kg on placebo.
Monthly prices in US dollars include the list price and self-pay offers. Each figure comes from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.
Mounjaro and Wellbutrin: the verdict
Speak with your prescriber first
From the drug interactions section of the Mounjaro label, word for word:
“MOUNJARO delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. Caution should be exercised when oral medications”
Source: FDA label (DailyMed).
What the Mounjaro label tells you
Wellbutrin (bupropion) is not named in the Mounjaro label. The following lines still apply to it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | It slows the emptying of your stomach, so the absorption of other pills may change. |
Source: Mounjaro label (DailyMed).
What the research found
- Interactions section of the drug label
- label interaction with oral medicines
- seizure risk factor; diabetes managed with insulin or pills
Source: FDA label (DailyMed).
A practical rule to follow
- Tell each prescriber about the other medicine, and do not change either dose by yourself.
- Let the person who prescribes your GLP-1 know about all the pills you take, and this one as well.
- Find out from your pharmacist whether a steady blood level is needed for any pills you take. You may need to have those checked when you start the medicine or increase the dose.
Source: FDA label (DailyMed).
Wellbutrin with other GLP-1s
Wellbutrin (bupropion) is not named in the drug interaction section of any of the 10 GLP-1 labels. Each of them carries the same general caution about pills you swallow, so the answer holds across the class.
The same question applies to Ozempic, Wegovy, Zepbound.
Source: FDA label (DailyMed).